Combined clinical and laboratory diagnostics of neurodegenerative disorders

Introduction Alzheimer’s disease (AD) is a neurodegenerative pathology that develops mainly in elderly and senile people. Objectives The aim of the study was comparative analysis results neuropsychological tests with indicators oral fluid buccal epithelium cytograms patients disease. Methods In main group 12 disease, m=76.25±4.89. There were cognitively healthy people control group. average MMSE score among observations 13.42±3.63. ADAS-COG scale used to detail impaired cognitive functions. concomitant compensated. content BDNF, TNF-α, IL1RA, IL-6, IL-8 determined blood serum. concentration salivary serum biomarkers by multiparametric fluorescence magnetic microspheres. Micronuclei, karyopycnosis, karyorexis, karyolysis cellular structures epithelium. material for cytological examination collected from inner surface cheek. Results When analyzing cytograms, attention drawn pronounced increase number cells micronuclei AD 1.8%; group, median 0.1% (p<0.05). A direct correlation established between binuclear level BDNF (r=0.646; p=0.03) AD. It also important note had significant immediate memory, correlates parameter naming objects. Conclusions Correlations amnesia, speech disorders, praxis, gnosis epithelium, especially severity karyopycnosis have been established, indicating process pathogenetically associated processes systemic inflammation degeneration Disclosure Interest None Declared